SubtiBank SubtiBank
rsbR [2017-03-10 12:17:35]
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rsbR [2017-03-10 12:17:35]

locus
BSU04670
pI
4.00
mw
30.00 kDa
protein length
274 aa Sequence Blast
gene length
822 bp Sequence Blast
function
control of SigB activity
product
activator of RsbT kinase activity, [SW|stressosome] sensor protein
essential
no
synonyms
ycxR,rsbRA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]

    • Gene

    Coordinates on the chromosome (coding sequence)
    519,408 -> 520,232

    The protein

    Catalyzed reaction/ biological activity

  • positive regulator of [protein|6C5397BA5839E4DB25B370B39B6DA702147DA8B7|YtvA]-dependent light activation of the [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB] stress response [Pubmed|22287516]
  • phosphorylated [protein|621357D1FB6AC1B0499732EFE226F982B26CE34E|RsbR] activates the kinase activity of [protein|ADC52A22950736A0435AEEEC43F7407878786A81|RsbT] [Pubmed|23320651]

    • Paralogous protein(s)

  • [protein|F53C527995909A1CFA72C7BF919DD10EE175C6D7|RsbRB], [protein|5EEEDE60CE9E5CDAEBAB0E03AABDF1DF62F1F002|RsbRC], [protein|979D7A45EAD97C99015029400A85795061BAA367|RsbRD], [protein|6C5397BA5839E4DB25B370B39B6DA702147DA8B7|YtvA]

    • [SW|Domains]

  • RsbRA is composed of an N-terminal nonheme globin domain and a highly conserved C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain. The C-terminal STAS domain is the target of the serine/threonine-specific kinase [protein|ADC52A22950736A0435AEEEC43F7407878786A81|RsbT] (see below).

    • Modification

  • phosphorylation on Thr-171 and Thr-205 by [protein|ADC52A22950736A0435AEEEC43F7407878786A81|RsbT] [Pubmed|21362065]

    • Structure

  • [PDB|2BNL] (N-terminal domain), [PDB|3VY9] (complete stressosome)
    • Expression and Regulation
    [[this]]

    Labs working on this gene/protein

  • [SW|Bill Haldenwang], San Antonio, USA
  • [SW|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]
  • [SW|Rick Lewis], Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/r.lewis homepage]

    • References

    Reviews

  • 19704888,16319496,20658979,23416074,28271471

    • Original Articles

  • 8002610,8682769,8682789,17726680,10781545,15583165,8824586,10329124,17158665,9179850,8808936,15312768,11244072,15342582,15378759,12950928,15466036,9179850,8955331,18832644,17726680,17218307,20019076,21602359,23320651,21362065,20935101,22287516,22609918,24599254