rsbR [2017-03-10 12:17:35]

Locus: BSU04670

Isoelectric point: 4.00

Molecular weight: 30.00 kDa

Protein length: 274 aa

Gene length: 822 bp

Function: control of SigB activity

Product: activator of RsbT kinase activity, stressosome sensor protein

Essential: no

Synonyms: ycxR,rsbRA

Genomic Context

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Categories containing this gene/protein

• Information processing → Regulation of gene expression → Sigma factors and their control → Control of sigma factors
• Groups of genes → Phosphoproteins → Phosphorylation on a Thr residue

Gene

Coordinates on the chromosome (coding sequence): 519,408 -> 520,232

The protein

Catalyzed reaction/ biological activity

• positive regulator of YtvA-dependent light activation of the SigB stress response PubMed
• phosphorylated RsbR activates the kinase activity of RsbT PubMed

Paralogous protein(s)

• RsbRB, RsbRC, RsbRD, YtvA

Domains

• RsbRA is composed of an N-terminal nonheme globin domain and a highly conserved C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain. The C-terminal STAS domain is the target of the serine/threonine-specific kinase RsbT (see below).

Modification

• phosphorylation on Thr-171 and Thr-205 by RsbT PubMed

Structure

• 2BNL (N-terminal domain), 3VY9 (complete stressosome)

Expression and Regulation: [[this]]

Labs working on this gene/protein

• Bill Haldenwang, San Antonio, USA
• Chet Price, Davis, USA homepage
• Rick Lewis, Newcastle, UK homepage

References

Reviews

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Original Articles

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